Evaluation of cytokines produced by β-hemolytic streptococcus in acute pharyngotonsillitis.

نویسندگان

  • Sydney Correia Leão
  • Ivanna Oliveira Leal
  • Hertaline Menezes do Nascimento Rocha
  • Tania Maria de Andrade Rodrigues
چکیده

INTRODUCTION The most common pathogen in bacteria lpharyngotonsillitis is group A β-hemolytic streptococcus, although groups B, C, F,and G have also been associated with pharyngotonsillitis. OBJECTIVE To assess the levels of the cytokines TNF-α, IL-6,IL-4, and IL-10 in bacterial pharyngotonsillitis caused by group A and non-A (groups B, C, F and G) β-hemolytic streptococcus. METHODS The study was conducted at a pediatric emergency care unit. The sample comprised children (5-9 years old) with acute bacterial pharyngotonsillitis diagnosed between December of 2011 and May of 2012. The research involved collection of blood samples from the patients, enzyme-linked immunosorbent assay detection of TNF-α, IL-6,IL-4, and IL-10, and collection of two oropharyngeal swabs for bacterial isolation. Additionally, the medical history of the study participants was also collected. RESULTS In the studied group (mean age: 5.93 years), higher pharyngotonsillitis incidence was observed in the female gender (64.76%). Higher incidence of tonsillar exudates was observed with groups A and C. No statistically significant differences in cytokine levels were observed among groups. However, the group A and the control group showed a difference in the IL-6 level (p=0.0016). CONCLUSIONS The Groups A and C showed higher cytokine levels than the Groups B and control, suggesting similar immunological patterns.

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عنوان ژورنال:
  • Brazilian journal of otorhinolaryngology

دوره 81 4  شماره 

صفحات  -

تاریخ انتشار 2015